Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of extrinsic and intrinsic cell death pathways. The diagram illustrates both intrinsic and receptor-mediated cell death mechanisms, highlighting secondary engagement of mitochondrial paths through the caspase-8 mediated cleavage of Bid. Inhibitors are depicted by broken lines. c-FLIP indicates cellular FLICE-like inhibitory protein, an endogenous inhibitor of caspase-8 activation; IAPs indicates inhibitor of apoptosis proteins.
