Table IV.
Downregulated mRNAs mainly involve the following signaling pathways.
| Pathway | Enrichment score | Genes |
|---|---|---|
| Pancreatic secretion | 3.298924 | AMY2A4//ATP1A3//CCKAR//CPA1//CTRB1//GNAS//ITPR2//KCNMA1//PNLIP//RAC1 |
| Endocrine and other factor-regulated calcium reabsorption | 3.101448 | ATP1A3//GNAS//KLK1B11//KLK1B24//KLK1B26//KLK1B5//KLK1B9 |
| Alzheimer's disease | 1.89058 | APBB1//ATP5G1//CACNA1C//CASP9//ITPR2//LPL//NDUFA11//NDUFA2//NDUFA6/NDUFC1//NDUFV3 |
| Endometrial cancer | 1.864948 | CASP9//FOXO3//ILK//SOS1//TCF7L2 |
| mTOR signaling pathway | 1.831442 | INS1//INS2//STK11//STRADA//VEGFB |
| Type I diabetes mellitus | 1.646775 | CPE//H2-K1//H2-Q6//INS1//INS2 |
| Neurotrophin signaling pathway | 1.575833 | FOXO3//MAP2K5//NGFRAP1//NTRK2//PTPN11//RAC1//SOS1//YWHAB |
| Aminoacyl-tRNA biosynthesis | 1.486088 | CARS2//IARS2//SARS//TARS//YARS |
| Maturity onset diabetes of the young | 1.475269 | INS1//INS2//NEUROD1 |
| Oxidative phosphorylation | 1.350224 | ATP5G1//ATP6V0A2//ATP6V1B2//NDUFA11//NDUFA2//NDUFA6//NDUFC1//NDUFV3 |
| Type II diabetes mellitus | 1.319886 | CACNA1C//HK2//INS1//INS2 |
mTOR, mammalian target of rapamycin.