Table V.
Downregulated mRNAs in signaling pathways.
| Pathway | Enrichment score | Genes |
|---|---|---|
| Transcriptional misregulation in cancer | 2.1658 | GOLPH3L//H3F3A//H3F3B//JMJD1C//MEF2C//RUNX1T1 |
| Dopaminergic synapse | 2.065915 | GNAS//GNB1//KCNJ6//PPP2R1B//PPP2R2A |
| Insulin secretion | 2.029172 | ATP1A3//CCKAR//GNAS//KCNMA1 |
| Morphine addiction | 1.945851 | ADRBK1//GNAS//GNB1//KCNJ6 |
| Alcoholism | 1.939052 | GNAS//GNB1//H3F3A//H3F3B//NTRK2//SOS1 |
| Endometrial cancer | 1.880095 | ILK//SOS1//TCF7L2 |
| Hippo signaling pathway | 1.809569 | LATS1//PPP2R1B//PPP2R2A//TCF7L2//YWHAB |
| Acute myeloid leukemia | 1.772872 | RUNX1T1//SOS1//TCF7L2 |
| Pancreatic secretion | 1.752665 | ATP1A3//CCKAR//GNAS//KCNMA1 |
| Dorso-ventral axis formation | 1.736718 | SOS1//SPIRE2 |
| mTOR signaling pathway | 1.694671 | RRAGD//STK11//STRADA |
| Viral carcinogenesis | 1.66536 | ACTN1//DDX3X//H2-Q6//IRF9//SCIN//YWHAB |
| Salivary secretion | 1.433264 | ATP1A3//GNAS//KCNMA1 |
| FoxO signaling pathway | 1.402263 | GABARAPL1//GADD45A//SOS1//STK11 |
| Hepatitis C | 1.392344 | IRF9//PPP2R1B//PPP2R2A//SOS1 |
| PI3K-Akt signaling pathway | 1.314372 | GNB1//PPP2R1B//PPP2R2A//SOS1//SPP1//STK11//YWHAB |
| Gap junction | 1.30117 | GNAS//MAP2K5//SOS1 |
mTOR, mammalian target of rapamycin; FoxO, forkhead box O; PI3K-Akt, phosphatidylinositol 3-kinase-protein kinase B.