Table XI.

miRNA-mRNA cross talks in the pancreatic islets of streptozotocin-induced diabetic mice.

miRNAs	mRNA	Signaling pathways	Biological functions
miR-705↑	ATP1A3↓	Insulin secretion ↓	Insulin secretion ↓
miR-450a-2-3p↑	CCKAR↓	Insulin secretion ↓	Insulin secretion ↓
miR-30b-3p↑	GNAS↓	Insulin secretion ↓	Insulin secretion ↓
miR-139-5p↑	KCNMA1↓	Insulin secretion ↓	Insulin secretion ↓
miR-669m-3p↑
miR-302a-3p↑	STK11↓	PI3K-Akt ↓	Apoptosis ↑
miR-302b-5p↑	GADD45A↓	PI3K-Akt ↓	Repair of DNA damage ↓
miR-491-5p↑
miR-133a-3p↑	GABARAPL1↓	PI3K-Akt ↓	Autophagy ↓
miR-133b-3p↑
miR-1956↑
miR-1956↑	PPP2R1B↓	FoxO ↓	Apoptosis ↑
miR-1956↑	PPP2R2A↓	FoxO ↓	Apoptosis ↑
miR-668-3p↑
miR-881-3p↑
miR-302a-3p↑	STK11↓	mTOR ↓	Autophagy ↓
miR-1953↑	STRADA↓	mTOR ↓	Autophagy ↓

miRNA and miR, microRNA;↑, upregulation;↓, downregulation; PI3K-Akt, phosphatidylinositol 3-kinase-protein kinase B; FoxO, forkhead box O; mTOR, mammalian target of rapamycin