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. 2015 Feb 12;3(3):365–370. doi: 10.3892/br.2015.427

Figure 1.

Figure 1.

Lipopolysaccharide (LPS)-induces damage to the renal function, which was followed by treatment with dexmedetomidine (DEX) and yohimbine (YOH) in the rats. The levels of (A) creatinine (Cr) and (B) blood urea nitrogen (BUN) when rats were exposed to LPS, DEX or YOH. LPS was injected (5 mg/kg) in the tail vein to generate the rat sepsis models. DEX (10 µg/kg) was pretreated 10 min before LPS injection. YOH (1 mg/kg) was injected intraperitoneally 30 min before DEX exposure. (n=8 in each group). *P<0.05 vs. Sham group; #P<0.05 vs. LPS group; &P<0.05 vs. LPS + DEX group.