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. 2014 Apr 16;6(8):5567–5581. doi: 10.18632/oncotarget.1901

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Copyright: © 2015 Lichner et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) miRNA expression pattern of CAKI-1 and ACHN parental cells and their RCC sphere derivative was compared by RT-qPCR-based screening. (B) Targets of differentially expressed miRNAs were analyzed by miRPath and TargetScan programs. The BMPR-SMAD1/5/8-mediated branch of TGFβ pathway is targeted by several miRNAs overexpressed in RCC spheres. The TGFBR2-SMAD2/3-mediated branch of the TGFβ pathway is predicted to be targeted by several miRNAs downregulated in RCC spheres.

(A) miRNA expression pattern of CAKI-1 and ACHN parental cells and their RCC sphere derivative was compared by RT-qPCR-based screening. (B) Targets of differentially expressed miRNAs were analyzed by miRPath and TargetScan programs. The BMPR-SMAD1/5/8-mediated branch of TGFβ pathway is targeted by several miRNAs overexpressed in RCC spheres. The TGFBR2-SMAD2/3-mediated branch of the TGFβ pathway is predicted to be targeted by several miRNAs downregulated in RCC spheres.