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. 2015 Jan 21;6(8):5597–5614. doi: 10.18632/oncotarget.3343

Figure 2. Expression and prognostic significance of CXCR4 in nodal and extranodal DLBCL.

Figure 2

(A-B) CXCR4 cell surface and CXCL12 mRNA expression levels in nodal and extranodal DLBCL. (C) CXCR4 cell surface expression correlated with decreased CXCL12 mRNA levels, both in nodal and extranodal DLBCL. (D) CXCR4 cell surface expression correlated with decreased CXCL12 mRNA levels in DLBCL patients without bone marrow (BM) involvement. (E-F) CXCR4 expression correlated with significantly poorer OS and PFS in the nodal DLBCL. (G-H) CXCR4 expression in extranodal sites did not correlate with survival significantly in DLBCL. (I-L) the prognostic significance of CXCR4 expression was independent of BM involvement.