Table 4. Up- and down-regulated genes in patients with CXCR4⁺ and CXCR4⁻ expression in overall DLBCL (false discovery rate [FDR] threshold: .01; P value cutoff: .000098; fold change cutoff: 1.41), GCB-DLBCL (FDR threshold: .10, P value cutoff: .000156), and ABC-DLBCL (FDR threshold: .05, P value cutoff: .000109).

CXCR4+ vs. CXCR4−
	DLBCL		GCB-DLBCL		ABC-DLBCL
	Upregulated	Downregulated	Upregulated	Downregulated	Upregulated	Downregulated
Signaling, ion channels	CXCR4, SFN, TMC5	DUSP4, GIMAP7, CSF2RB, CECR1	CNR1, TMC5, STIM2, DOK5, PTHLH	GABBR1, UBD, DUSP4, FYB, PTPN6, LAMP1, NTNG2, RASA3	YTHDF2	FYN, FYB, PBXIP1, MS4A6A, PLCD1, ACVRL1, ADAP2
Cytokine, chemokine		CXCL12, CCL2				CXCL12, TNFSF12
Immune responses, inflammation	IRF4, TCF4	HLA-DQA1/HLA-DQA2, HLA-DRB1/HLA-DRB4, TRBC1, GIMAP1, FYN, FYB, LCP2, CD3E, SIRPG, SAMHD1, C3, LAT	POU2AF1	LCP2, LILRB2, SAMHD1, HLA-E		TRBC1, STAT4, C2, LST1
DNA recombination, mitotic regulation	AICDA, HELLS, ZWINT		MLLT11, SGOL2, FRY		AICDA, HELLS, ANLN, CCDC52, CDK2, CEP152, RAD54B
Transcription regulation	FOXP1, CDCA7, AFF3	BCL11B		MKL1	MYEF2	BCL11B, TXNIP, CTBP2
mRNA editing, translation		ADARB1	HRSP12		FARSA	SAMD4A
Metabolism	TMEM97, FAM72A		PTPLAD1	RGL1, CYP46A1	HILPDA, CYP51A1, MOCOS	SULT1A3/SULT1A4, SULT1A2
Transport, protein modification, folding, chaperone, degradation	DNAJC6	RTN1, PADI2	TCL1A, DNAJC6, AP4S1	RTN1, APOL3, PARP14, PSAP, NAGA, CYLD	SUGT1	FOLR2, SLC46A1, SLC7A6OS, MARCH2
Cell adhesion, cytoskeleton, collagen, extracelluar matrix		DPT, EPB41L2, ITGB2, UTRN SH3KBP1	EML6, STK33	ITGB2, MYO1F	FLJ23834, TTC30A, NPHP1	MFAP4, ITGAL, EVL, CD6, FGD3, SIGLEC7
Differentiation, development		ITM2A, SLAMF8		SLFN5	FIGNL1, DAZAP1	TMEM2
Apoptosis, autophage	PEG10	MAF, RASSF4		RASSF4, GIMAP5	PEG10, PIM2, BECN1	TBRG1
IncRNA genes, unknown function	RNF183, P704P, C13orf18, FAM129C, KLHL23	C16orf54, EPSTI1	TCL6, ST7OT4, LOC100131683	C6orf204, FAM105A	DPY19L2P2, C9orf40, CCDC117	LOC100131096, LOC400236, LOC646014, GDPD3, N4BP2L1