Table 1: Clinical features of patients between CD5+ and CD5− de novo DLBCL, and patients between CD5+ and CD5− ABC-DLBCL in the training set.
| Variables | CD5+ | CD5− | CD5+ vs. CD5− | CD5+ ABC | CD5− ABC | CD5+ ABC vs. CD5− ABC |
|---|---|---|---|---|---|---|
| N(%) | N(%) | N(%) | N(%) | |||
| Age, years | ||||||
| < 60 | 7(23.3) | 225(44.3) | .024 | 5(21.7) | 83(35.2) | .19 |
| ≥ 60 | 23(76.7) | 283(55.7) | 18(78.3) | 153(64.8) | ||
| Sex | ||||||
| F | 14(45.2) | 210(41.3) | .67 | 10(43.5) | 96(40.7) | .79 |
| M | 17(54.8) | 298(58.7) | 13(56.5) | 140(59.3) | ||
| Stage | ||||||
| I - II | 9(32.1) | 235(47.8) | .11 | 7(31.8) | 91(39.6) | .48 |
| III - IV | 19(67.9) | 257(52.2) | 15(68.2) | 139(60.4) | ||
| B-symptoms | ||||||
| No | 13(46.4) | 319(65.9) | .036 | 10(45.5) | 137(60.6) | .17 |
| Yes | 15(53.6) | 165(34.1) | 12(54.5) | 89(39.4) | ||
| LDH level | ||||||
| Normal | 9(32.1) | 182(38.8) | .48 | 7(30.4) | 79(36.2) | .58 |
| Elevated | 19(67.9) | 287(61.2) | 16(69.6) | 139(63.8) | ||
| No. of extranodal sites | ||||||
| 0 - 1 | 22(76.7) | 369(77.2) | .75 | 17(78.3) | 169(74.2) | .99 |
| ≥ 2 | 8(23.3) | 117(22.8) | 6(21.7) | 60(25.8) | ||
| ECOG performance status | ||||||
| 0 - 1 | 17(60.7) | 387(85.1) | .0007 | 14(60.9) | 179(82.9) | .01 |
| ≥ 2 | 11(39.3) | 68(14.9) | 9(39.1) | 37(17.1) | ||
| Size of largest tumor | ||||||
| < 5cm | 9(45.0) | 224(59.4) | .2 | 7(43.8) | 104(58.1) | .27 |
| ≥ 5cm | 11(55.0) | 153(40.6) | 9(56.3) | 75(41.9) | ||
| IPI score | ||||||
| 0 - 2 | 13(48.3) | 310(63.4) | .05 | 10(43.5) | 127(55.2) | .28 |
| 3 - 5 | 16(51.7) | 182(36.6) | 13(56.5) | 103(44.8) | ||
| Therapy response | ||||||
| CR | 20(66.7) | 396(78) | .15 | 16(69.6) | 192(78) | .35 |
| PR | 6 | 64 | 5 | 34 | ||
| SD | 2 | 20 | 0 | 9 | ||
| PD | 2 | 28 | 2 | 11 | ||
| BM involvement | ||||||
| Yes | 11(42.3) | 39(8.9) | <.0001 | 9(47.4) | 20(9.7) | .0001 |
| No | 15(57.7) | 399(91.1) | 10(52.6) | 187(90.3) | ||
| COO | ||||||
| GCB | 7(23.3) | 268(53.2) | .002 | |||
| ABC | 23(76.7) | 236(46.8) | ||||
Note: LDH, serum lactate dehydrogenase; IPI, International Prognostic Index; BM, bone marrow; COO, cell-or-origin; GCB, germinal center B-like; ABC, activated B-cell like.