Table 4: Differentially expressed genes between patients with CD5⁺ and CD5⁻ DLBCL.

Function categories	Numbers	Upregulated gene names	Numbers	Downregulated gene names
Antiapoptosis	2	BCL2, TNFAIP8
T-cell and B-cell receptor signaling	7	CARD11, CLECL1, IGHM, LYN, PTPN2, SIT1, SH3BP5ⱡ
Hematopoietic development, immune response, central nervous system, signaling including NF-kB, MAPK, Wnt and calcium-dependent pathways	10	ARHGAP17, BSPRY, C2orf34ⱡ, CXXC5ⱡ, SIPA1L3ⱡ, OGT, MPEG1, OAS1ⱡ, TMEM149, GLYR1*	14	APCDD1ⱡ, CLEC11A, DZIP1, INHBA#x2C61;, PI15ⱡ, PDE4D, SGK1, SOBP, CAMK2N1*, FGF1*, FGF17*, PPM1L*, PTPRR*, SLC6A9*
Cell cycle progression	3	CCND2, CDK3, TLK1	1	NEK6ⱡ
Transcriptional activator/repressor	11	CREB3L2, ETV6, FOXP1, IRF2BP2, JARID2, TCF4ⱡ, ZNF589, RBM39*, ANKRD12*, ZNF614*, ZNF814*	7	LMO2, LMO4, MAML3, TFEC, MYBL1, ZNF709, LHX2*
mRNA stability, RNA regulation	2	LUC7L, SERBP1	1	SREK1
Protein modification, processing, degradation, transporter	3	ERP29, FAM175Bⱡ, SLC38A2	2	CTSK, UGGT2ⱡ
Cytoskeletal protein, extracellular matrix, cell adhesion, migration	1	PDLIM1	14	CCBE1, COL5A1, COL6A3, ENPP3, FAM198Bⱡ, FN1, LTBP1, PCDH9, PTK2, PTPRB, RAPH1, BAIAP2L1*, ITGBL1*, MYO7A*
Metabolism	1	ST3GAL2*
IncRNA, unknown function and others	12	C13orf18ⱡ, CXorf21, FAM129Cⱡ, LOC100506168, LOC202781, KLHL14, KIAA0040ⱡ, LIC7L, MAPS8, RRP7A, NPIP*, NAPSB*	11	CRNDE,CCDC144B, C15orf48, FRMD6, GLT1D1, LOC100288271ⱡ, LOC100506457ⱡ, LOC100133790ⱡ, LOC440864, KIAA1211, SAMD12, LOC100130815*

Note: Genes marked by

^*are those identified in comparison of CD5⁺ vs. CD5⁻ ABC-DLBCLs; genes marked by

^ⱡare those identified in both CD5⁺ vs. CD5⁻ DLBCL and CD5⁺ vs. CD5⁻ ABC-DLBCL. Bolded genes are involved in nervous system development or function.