Fig. 3. Functional classification of identified proteins and biological network analysis.

Cellular component (A) and biological processes (B) interested by the 22 differentially expressed proteins assessed by BINGO search and summarized according to functions and location in the cell. For each biological process and cellular component the number of proteins in each class is given. Enrichment analysis of cellular component (C) and biological process networks (D) generated by BINGO software for the 22 differentially expressed proteins. The color bar in right lower quadrant indicates the level of significance from low (yellow) to high (orange). The size of each node is proportional to the number of proteins annotated with that term. Only statistically significant sub-networks are shown in the figure (p<0.01).