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(A–B) Rotated views of ASP3026 (C atoms shown in orange) docking into ALK-WT. (C–D) Docking of ASP3026 to ALK mutants (C, ALK-D1203N; D, ALK-E1210K) showing a different pose (C atoms in purple). Mutations spots and DFG motif residues are showed in licorice representation (C atoms in cyan and iceblue, respectively).
