Table 3. Relative Resistance indexes.
ASP3026 | AP26113 | alectinib | crizotinib | ceritinib | PF-06463922 | |
---|---|---|---|---|---|---|
Ba/F3 parental | 41 | 179 | 116 | 59 | 77 | 2508 |
WT | 1 | 1 | 1 | 1 | 1 | 1 |
G1128S | 15 | 0.7 | 2.1 | 2.8 | 5.0 | 10 |
C1156F | 19 | 21 | 39 | 1.6 | 11 | 155 |
I1171N | 7.4 | 5.2 | 28 | 5.0 | 9.1 | 9.5 |
I1171T | 6.4 | 7.5 | 19 | 2.3 | 3.99 | 146 |
F1174I | 2.6 | 0.9 | 0.8 | 1.0 | 0.6 | 1.9 |
N1178H | 2.4 | 2.5 | 1.2 | 0.9 | 2.1 | 2.4 |
E1210K | 11 | 15 | 31 | 1.97 | 9.1 | 57 |
C1156F/D1203N | 40 | 10 | 4.0 | 11 | 12 | 54 |
RR legend | |
---|---|
< 2 | Sensitive |
2–4 | Slightly resistant |
4–10 | Fairly resistant |
> 10 | Highly resistant |