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. 2014 Dec 25;6(8):5735–5748. doi: 10.18632/oncotarget.3240

Figure 1. ST7612AA1 reduces HDAC activity and induces apoptosis of human cancer cells.

Figure 1

A) Chemical structure of the prodrug ST7612AA1 and its drug ST7464AA1. B) Assessment of a dose-dependent effect of ST7612AA1 on acetylation of alpha-tubulin and histone H4 in NCI-H460 NSCLC cells after 3 h exposure. SAHA 5 μM was used as internal positive reference. To control for equal loading, blots were stripped and reprobed with antibodies against tubulin and histone H4. C) Assessment of ST7612AA1-induced apoptosis in lymphoma cell lines. Y-axis, percentage of Annexin V positive cells after exposure to ST7612AA1 (250 nM) for 72 hrs. The TP53 gene status of each cell line was shown below the X-axis.