Table 3. Pharmacokinetic parameters for ST7464AA1 in CD1 mice receiving a single oral dose of 120 mg/kg of ST7612AA1 derived from the plasma concentration vs time data according to a model independent approach for sparse data sampling.
| Tmax (h) | Cmax* (ng/mL) | Tlast (h) | Clast (ng/mL) | AUClast* (h* ng/mL) | AUCINF (h*ng/mL) | CL/F (mL/h/kg) | Vz/F (mL/kg) | T1/2 (h) |
|---|---|---|---|---|---|---|---|---|
| 0.5 | 1577±478 | 6.0 | 303 | 3747±299 | 5506 | 21795 | 119340 | 3.8 |
Cmax: maximum plasma concentration; Tmax: time of Cmax; Clast: last quantifiable concentration; Tlast: time of Clast; AUClast: (area under the concentration vs time curve from 0 to Tlast; AUCINF: area under the concentration vs time curve from 0 to infinity; T1/2: terminal half-life; CL/F: apparent systemic clearance; Vz/F: apparent terminal volume of distribution
*
mean ± SEM.