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. 2015 Feb 28;6(8):5877–5888. doi: 10.18632/oncotarget.3463

Figure 5. CXCL5 rescued invasion and antagonized tumor repression by DACH1.

Figure 5

(A) The reciprocal mRNA expression between DACH1 and CXCL5 in normal lung epithelial cell line and 7 lung cancer cell lines from GSE7670. (B) The reciprocal mRNA expression between DACH1 and CXCL5 in NSCLC tissues from GSE7670. Addition of CXCL5 enhanced migration (C) and invasion (D) of A549 and A-427 cell expressing DACH1. Neutralized antibody to CXCL5 decreased migration (E) and invasion (F) of A549 and A-427 cells. Growth curve (G), weight (H) and representative images (I) of tumors from A549-DACH1 stable cells with ectopic CXCL5 expression versus vector control. (J) Representative immunohistochemical images of CXCL5 from A549-DACH1 cells with or without CXCL5 transduction.