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. 2015 Jan 21;6(8):5947–5962. doi: 10.18632/oncotarget.3335

Figure 2. GSK3α, but not GSK3β is necessary for prostate cancer cell colony formation in vitro and tumor growth in vivo.

Figure 2

(A) Figure (upper panel) and bar graph (lower panel) showing colony formation of PC3 cells with stable knockdown of GSK3α and GSK3β, compared to PC3 cells expressing control ShRNA (n=4). (B) Figure (upper panel) and bar graph (lower panel) showing colony formation of DU145 cells with stable knockdown of GSK3α and GSK3β, compared to PC3 cells expressing control ShRNA (n=4). (C) Figure (upper panel) and bar graph (lower panel) showing colony formation of DU145 cells with stable knockdown of GSK3α and GSK3β, compared to PC3 cells expressing control ShRNA (n=4). (D) Images of PC3 cell tumor xenografts collected from athymic nude mice with cells expressing control (upper), GSK3α (middle) and GSK3β (lower) ShRNAs. (E) Figure showing tumor volume of the PC3 xenografts in athymic nude mice expressing control, GSK3α and GSK3β ShRNAs on day 4, 6, 8, 12 and 16 after injection (n=6). (F) Bar graph showing tumor weight of the PC3 xenografts in athymic nude mice expressing control, GSK3α and GSK3β ShRNAs collected on day 16 after injection (n=6). Data is shown as Mean + SD; *p <0.05.