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. 2015 Jan 21;6(8):5947–5962. doi: 10.18632/oncotarget.3335

Figure 6. GSK3α gene silencing has improved therapeutic benefits as compared to GSK3β in inhibiting prostate cancer colonization to lungs.

Figure 6

(A) Figure showing serial sections of the lungs collected from athymic nude mice 16 days after intravenous (tain-vein) administration of PC3 cells expressing control, GSK3α and GSK3β ShRNA and perfused with india ink to visualize the metastatic tumor nodules. (B) Figure showing image conversion using Image J software to clearly visualize and quantify metastasized tumor nodules in the lungs. (C) Bar graph showing the area of tumor growth in each lung serial sections collected 16 days after intravenous administration of PC3 cells expressing control, GSK3α and GSK3β ShRNA showing the effect of GSK3α and GSK3β gene knockdown on their ability to metastasize to the lungs (n=5). Data is shown as Mean + SD; *p <0.01.