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. 2015 Feb 28;6(8):5978–5989. doi: 10.18632/oncotarget.3468

Figure 4. Thiamine metabolism is a key determinant of tumor specific radiosensitivity.

Figure 4

A) Colony formation of the tumor lines HeLa, CAL51, H460, HCT-116, PSN-1 and BT-549 cells irradiated after 4 days incubation with DMSO (control) or 10 μM PyrH. B) Colony formation of normal lung fibroblasts lines HFL-1 and MRC5 cells irradiated after 4 days incubation with DMSO (control) or 10 μM PyrH. CFA: representative of three independent experiments, data points presented as mean +/− SD from triplicate wells, p-values generated by factorial 2-way ANOVA. Sensitization enhancement ratio at 0.10 surviving fraction (SER10) calculated from non-linear regression of linear quadratic model.