Figure 5. Schematic representation of the method used for the analysis of Cir-ITCH regulated progress of ESCC.

Cir-ITCH is a potential tumor suppressor acting through the control of miRNAs activity such as miR-7, miR-17, miR-214 and increase the concentration of ITCH, resulting in suppression of the canonical Wnt pathway by degradation of phosphorylated Dvl2, and inhibited the oncogene c-myc expression therefore inhibit canonical Wnt signaling.