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. 2015 Jan 31;6(8):6160–6178. doi: 10.18632/oncotarget.3349

Figure 1. NIBP expression is upregulated in most tumor tissues.

Figure 1

(A) A TissueScan cancer survey qPCR analysis identified the increased expression of NIBP mRNA in most tumor tissues. The data represent fold changes of NIBP mRNA expression in a tumor sample to a mean value of the corresponding normal tissues after β-actin normalization. (B) Semi-quantitative evaluation of NIBP-like immunoreactivity in the frozen tissue microarray from indicated cancer patients showed dramatic increases in NIBP protein expression in most tumor tissues as compared to corresponding normal tissues. A 5-grade scoring method was employed on the basis of the area and positivity of immunofluorescent staining. (C) A high-density reverse-phase cancer protein lysate array was evaluated for NIBP protein expression in 11 tumor tissues at various concentrations (250 and 500 μg/ml) of loaded protein lysates. * p<0.05 and ** P<0.01 indicates significant difference between tumor samples and corresponding normal tissues using Student's t test.