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. 2015 Jan 31;6(8):6179–6190. doi: 10.18632/oncotarget.3350

Figure 3. Fiber expression is directly or indirectly regulated, in miR-148a positive tissues, following Ad-L5-8miR148aT or Ad-E1A-8miR148aT systemic delivery.

Figure 3

(A). Representative Western blots of Fiber in liver extracts from wild type mice intravenously injected with 2×1010 vp/mice of Ad-wt, Ad-E1A-8miR148aT and Ad-L5-8miR148aT. Quantification of Fiber signal normalized to GAPDH expression (n=10). Values are expressed relative to Fiber content from Ad-wt treated mice. * and ** denote p<0.05 and p<0.01, respectively. (B). Relative expression of E1A, Hexon and Fiber compared to Ad-wt assessed by RT-qPCR in liver, pancreas and kidneys (n=10/treatment). * and ** denote p<0.05 and p<0.01, respectively.