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. 2015 Jan 31;6(8):6203–6217. doi: 10.18632/oncotarget.3357

Figure 3. Supplemental nutrients had no effect on the autophagy and liver injury of dasatinib.

Figure 3

ICR mice were randomly divided into 4 groups (n=6 mice) and treated with supplemental nutrients (10 ml/kg), dasatinib (50 mg/kg) or both for 30 days. A. Average body weight. B. Serum was analyzed for ALT, AST and LDH levels. C. Total liver lysates were analyzed by western blot using antibodies against cleaved caspase-3, cleaved PARP, LC3, p-p38 and β-actin. D. Liver sections were stained with H&E for histopathological analysis (magnification=100× or 400×, scale bar=50 μm). Black arrows denote necrotic hepatocytes. ***, P<0.001 for significant differences compared to the vehicle control. DASA=dasatinib.