Figure 5. Protein features that affect repeat specificity.

(a) RVD identity. ΔΔG values from the model are indicated for each repeat type with each base. In addition, the ΔΔGs for the four bases at the 5′ T position, which are contacted by the N-terminal region (NTR), are shown. (b) Position and length. The effects of repeat position and protein length on the specificity of each repeat type are shown. (c) Effect of neighbouring repeats or terminal regions on specificity. For each repeat type and the NTR, the bar heights display the effect on specificity for different neighbours in the N- or C-terminal direction (orange and teal, respectively). The quantity shown is the log₂ ratio between the PWM frequency predicted with and without the presence of a given neighbour in the model. CTR refers to the C-terminal region; repeats with the CTR as the C-terminal neighbour are the half-repeats in the final repeat position.