Table 3.
Potential host AMPylation substrates for SidM
| Symbol | DNASU Gene ID |
Description | NAPPA Z-score | AMPylation assay |
Previously reported |
|
|---|---|---|---|---|---|---|
| SidM* | SidM | |||||
| Rab1B | 391 | Ras-related protein Rab-1B | 0.5 | 10.2 | + | (9) |
| Rab2A | 5862 | Ras-related protein Rab-2A | / | Ring | - | No AMPylation (31) |
| Rab2B | 84932 | Ras-related protein Rab-2B | / | Ring | + | |
| Rab4B | 53916 | Ras-related protein Rab-4B | / | Ring | + | (9) |
| Rab8A | 4218 | Ras-related protein Rab-8A | 1.3 | 3.6 | + | AMPylation (9); No AMPylation (31) |
| Rab8B | 79165 | Ras-related protein Rab-8B | −0.8 | 21.9 | + | |
| Rab10 | 10890 | Ras-related protein Rab-10 | 0.6 | 4.8 | + | |
| Rab11A | 8766 | Ras-related protein Rab-11A | / | Ring | - | (9) |
| Rab11B | 9230 | Ras-related protein Rab-11B | / | Ring | + | |
| Rab13 | 5872 | Ras-related protein Rab-13 | / | Ring | + | (9) |
| Rab27A | 5879 | Ras-related protein Rab-27A | 0.1 | 4.3 | - | No AMPylation (9) |
| Rab35 | 11021 | Ras-related protein Rab-35 | −1.5 | 4.3 | + | (31) |
| OCEL1 | 79629 | Occludin/ELL-domain- containing protein 1 |
0.2 | 3.8 | + | |
| RARRES3 | 5920 | Retinoic acid receptor responder 3 |
/ | Ring | + | |
| IDI2 | 91734 | Isopentenyl-diphosphate delta isomerase 2 |
/ | Ring | + | |
| KIAA0652 / ATG13 |
9776 | Autophagy related 13 | / | Ring | - | |
| GGT1 | 2678 | Gamma-glutamyltransferase 1 |
1.2 | 3.4 | - | |
| DECR2 | 26063 | 2,4-Dienoyl CoA reductase 2, peroxisomal |
0.5 | 3.4 | - | |
| DERL1 | 79139 | Derlin 1 | −0.3 | 4.7 | - | |
| CREB1 | 1385 | cAMP responsive element binding protein 1 |
1.2 | 3.8 | - | |
| PAK4 | 10298 | p21 protein (Cdc42/Rac)- activated kinase 4 |
/ | Ring | - | |
| GPAM | 57678 | Glycerol-3-phosphate acyltransferase, mitochondrial |
/ | Ring | - | |
| CDCP2 | 242603 | CUB domain containing protein 2 |
/ | Ring | - | |
| HRASLS2 | 54979 | HRAS-like suppressor 2 | / | Ring | - | |
| ERMN | 57471 | Ermin, ERM-like protein | / | Ring | - | |
| TTC5 | 91875 | Tetratricopeptide repeat domain 5 |
/ | Ring | - | |
| ARHGAP11A | 9824 | Rho GTPase activating protein 11A |
/ | Ring | - | |
| C21orf2 | 755 | Chromosome 21, open reading frame 2 |
/ | Ring | - | |
Abbreviations: SidM*, SidM(D110/112A); /, not listed because selection based on Ring; + or -, positive or negative result in bead-based AMPylation assay.