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FGFR1 gene amplification in small-cell lung cancer (silver in situ hybridization, 400× original magnification). A, FGFR1 signals are black; CEN8 signals are red in nuclei. FGFR1 amplification (ratio = 8); a, nonamplified FGFR1 (ratio = 1). FGFR, fibroblast growth factor receptor.
