Table 2.
Univariate and multivariate analyses of the association of the prognostic factors and the LMR with RFS
| Factors | Univariate analysis HR (95% CI) | P-value | Multivariate analysis HR (95% CI) | P-value |
|---|---|---|---|---|
| Age at diagnosis | ||||
| <45 years | 1 | <0.001 | 1 | 0.084 |
| ≥45 years | 0.443 (0.286–0.687) | 0.657 (0.408–1.058) | ||
| Pathological type | ||||
| SCC | 1 | 0.866 | ||
| Non-SCC | 0.965 (0.639–1.458) | |||
| Tumor grade | ||||
| G1 | 1 | 0.024 | 1 | 0.276 |
| G2 | 1.479 (1.054–2.076) | 1.232 (0.846–1.793) | ||
| G3 | ||||
| Depth of stromal invasion | ||||
| <2/3 | 1 | <0.001 | 1 | 0.043 |
| ≥2/3 | 1.574 (1.264–1.961) | 1.398 (1.010–1.935) | ||
| Lymphovascular space invasion | ||||
| Yes | 1 | <0.001 | 1 | 0.073 |
| No | 2.718 (1.704–4.335) | 1.608 (0.956–2.705) | ||
| Lymph node metastasis | ||||
| No | 1 | <0.001 | 1 | <0.001 |
| 1 | 1.854 (1.567–2.194) | 1.735 (1.457–2.065) | ||
| 2 | ||||
| ≥3 | ||||
| Tumor stage | ||||
| Ib1 | 1 | 0.015 | 1 | 0.072 |
| Ib2 | 1.425 (1.072–1.893) | 1.329 (0.975–1.812) | ||
| IIa | ||||
| Parametrial involvement | ||||
| Yes | 1 | 0.385 | ||
| No | 0.418 (0.058–2.998) | |||
| Adjuvant therapy | ||||
| None | 1 | 0.001 | 1 | 0.816 |
| Radiotherapy | 1.778 (1.280–2.468) | 0.946 (0.591–1.514) | ||
| Chemoradiotherapy | ||||
| LMR | ||||
| ≤2.87 | 1 | <0.001 | 1 | <0.001 |
| >2.87 | 0.373 (0.247–0.563) | 0.439 (0.279–0.693) | ||
Abbreviations: CI, confidence interval; HR, hazard ratio; LMR, lymphocyte/monocyte ratio; RFS, recurrence-free survival; SCC, squamous cell carcinoma.