Table 2.
Factors | Univariate analysis HR (95% CI) | P-value | Multivariate analysis HR (95% CI) | P-value |
---|---|---|---|---|
Age at diagnosis | ||||
<45 years | 1 | <0.001 | 1 | 0.084 |
≥45 years | 0.443 (0.286–0.687) | 0.657 (0.408–1.058) | ||
Pathological type | ||||
SCC | 1 | 0.866 | ||
Non-SCC | 0.965 (0.639–1.458) | |||
Tumor grade | ||||
G1 | 1 | 0.024 | 1 | 0.276 |
G2 | 1.479 (1.054–2.076) | 1.232 (0.846–1.793) | ||
G3 | ||||
Depth of stromal invasion | ||||
<2/3 | 1 | <0.001 | 1 | 0.043 |
≥2/3 | 1.574 (1.264–1.961) | 1.398 (1.010–1.935) | ||
Lymphovascular space invasion | ||||
Yes | 1 | <0.001 | 1 | 0.073 |
No | 2.718 (1.704–4.335) | 1.608 (0.956–2.705) | ||
Lymph node metastasis | ||||
No | 1 | <0.001 | 1 | <0.001 |
1 | 1.854 (1.567–2.194) | 1.735 (1.457–2.065) | ||
2 | ||||
≥3 | ||||
Tumor stage | ||||
Ib1 | 1 | 0.015 | 1 | 0.072 |
Ib2 | 1.425 (1.072–1.893) | 1.329 (0.975–1.812) | ||
IIa | ||||
Parametrial involvement | ||||
Yes | 1 | 0.385 | ||
No | 0.418 (0.058–2.998) | |||
Adjuvant therapy | ||||
None | 1 | 0.001 | 1 | 0.816 |
Radiotherapy | 1.778 (1.280–2.468) | 0.946 (0.591–1.514) | ||
Chemoradiotherapy | ||||
LMR | ||||
≤2.87 | 1 | <0.001 | 1 | <0.001 |
>2.87 | 0.373 (0.247–0.563) | 0.439 (0.279–0.693) |
Abbreviations: CI, confidence interval; HR, hazard ratio; LMR, lymphocyte/monocyte ratio; RFS, recurrence-free survival; SCC, squamous cell carcinoma.