Table 3.
Univariate and multivariate analyses of the association of prognostic factors and LMR with the time to OS
| Factors | Univariate analysis HR (95% CI) | P-value | Multivariate analysis HR (95% CI) | P-value |
|---|---|---|---|---|
| Age at diagnosis | ||||
| <45 years | 1 | 0.002 | 1 | 0.244 |
| ≥45 years | 0.447 (0.265–0.753) | 0.715 (0.406–1.258) | ||
| Pathological type | ||||
| SCC | 1 | 0.778 | ||
| Non-SCC | 0.928 (0.553–1.557) | |||
| Tumor grade | ||||
| G1 | 1 | 0.007 | 1 | 0.056 |
| G2 | 1.783 (1.175–2.707) | 1.574 (0.989–2.507) | ||
| G3 | ||||
| Depth of stromal invasion | ||||
| <2/3 | 1 | 0.001 | 1 | 0.063 |
| ≥2/3 | 1.570 (1.208–2.042) | 1.455 (0.980–2.161) | ||
| Lymphovascular space invasion | ||||
| Yes | 1 | 0.002 | 1 | 0.455 |
| No | 2.451 (1.392–4.317) | 1.269 (0.679–2.371) | ||
| Lymph node metastasis | ||||
| No | 1 | <0.001 | 1 | <0.001 |
| 1 | 1.743 (1.425–2.132) | 1.596 (1.292–1.972) | ||
| 2 | ||||
| ≥3 | ||||
| Tumor stage | ||||
| Ib1 | 1 | 0.031 | 1 | 0.203 |
| Ib2 | 1.454 (1.034–2.046) | 1.271 (0.879–1.838) | ||
| IIa | ||||
| Parametrial involvement | ||||
| Yes | 1 | 0.642 | ||
| No | 0.626 (0.087–4.513) | |||
| Adjuvant therapy | ||||
| None | 1 | 0.004 | 1 | 0.842 |
| Radiotherapy | 1.776 (1.199–2.631) | 0.943 (0.532–1.674) | ||
| Chemoradiotherapy | ||||
| LMR | ||||
| ≤2.87 | 1 | <0.001 | 1 | 0.001 |
| >2.87 | 0.381 (0.233–0.622) | 0.417 (0.244–0.714) | ||
Abbreviations: CI, confidence interval; HR, hazard ratio; LMR, lymphocyte/monocyte ratio; OS, overall survival; SCC, squamous cell carcinoma.