Table 3.
Factors | Univariate analysis HR (95% CI) | P-value | Multivariate analysis HR (95% CI) | P-value |
---|---|---|---|---|
Age at diagnosis | ||||
<45 years | 1 | 0.002 | 1 | 0.244 |
≥45 years | 0.447 (0.265–0.753) | 0.715 (0.406–1.258) | ||
Pathological type | ||||
SCC | 1 | 0.778 | ||
Non-SCC | 0.928 (0.553–1.557) | |||
Tumor grade | ||||
G1 | 1 | 0.007 | 1 | 0.056 |
G2 | 1.783 (1.175–2.707) | 1.574 (0.989–2.507) | ||
G3 | ||||
Depth of stromal invasion | ||||
<2/3 | 1 | 0.001 | 1 | 0.063 |
≥2/3 | 1.570 (1.208–2.042) | 1.455 (0.980–2.161) | ||
Lymphovascular space invasion | ||||
Yes | 1 | 0.002 | 1 | 0.455 |
No | 2.451 (1.392–4.317) | 1.269 (0.679–2.371) | ||
Lymph node metastasis | ||||
No | 1 | <0.001 | 1 | <0.001 |
1 | 1.743 (1.425–2.132) | 1.596 (1.292–1.972) | ||
2 | ||||
≥3 | ||||
Tumor stage | ||||
Ib1 | 1 | 0.031 | 1 | 0.203 |
Ib2 | 1.454 (1.034–2.046) | 1.271 (0.879–1.838) | ||
IIa | ||||
Parametrial involvement | ||||
Yes | 1 | 0.642 | ||
No | 0.626 (0.087–4.513) | |||
Adjuvant therapy | ||||
None | 1 | 0.004 | 1 | 0.842 |
Radiotherapy | 1.776 (1.199–2.631) | 0.943 (0.532–1.674) | ||
Chemoradiotherapy | ||||
LMR | ||||
≤2.87 | 1 | <0.001 | 1 | 0.001 |
>2.87 | 0.381 (0.233–0.622) | 0.417 (0.244–0.714) |
Abbreviations: CI, confidence interval; HR, hazard ratio; LMR, lymphocyte/monocyte ratio; OS, overall survival; SCC, squamous cell carcinoma.