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. 2015 Jun 16;16:34. doi: 10.1186/s12868-015-0171-5

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© Dickson et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overexpression of SD2 in neurons blocks CCG-17444 activity. P19-derived neurons were transfected with a control vector or SD2 expression vector (Shroom3 aa 1,762–1,986) and treated with DMSO (vehicle control) or 25 μM CCG-17444 for 24 h prior to analysis of neurite length. Ectopic expression of wild type but not Cys254Ala SD2 reverses the action of CCG-17444, demonstrating that the mechanism of action of CCG-17444 in neurons is inhibition of SD2 function (n = 3, *p < 0.0001, **p < 0.05 Student’s t test).