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. 2015 Apr 20;5(6):e00339. doi: 10.1002/brb3.339

Table 3.

Whole-brain and ROI results for (a, b) the ANOVA happy versus neutral contrast, and (c) correlation between self-reported mood ratings difference and brain perfusion maps difference for happy minus neutral mood induction conditions

Region Side Cluster size (voxels) Peak MNI coordinates Z score P (FWE) AlphaSim corrected1
x y z
(a) Happy > Neutral
 Whole-brain analysis
  Brainstem, cingulate gyrus (incl. BA 32), medial frontal gyrus 4461 −4 0 −16 3.89 0.009 Pcorr < 0.05
−6 16 42 3.56
−14 14 50 3.53
  Subgyral (parietal and frontal lobes) L 477 −22 −36 54 3.52 0.913 Pcorr < 0.05
−28 −38 38 3.47
−20 −40 40 2.75
ROI analysis
 sgACC L 507 −4 2 −16 3.81 0.005
 Ventral striatum 271 −4 6 −12 3.38 0.010
 Amygdala 13 −16 −8 −14 2.72 0.051
(b) Happy < Neutral
 Whole-brain analysis
  Inferior parietal lobule (BA 40) R 6112 56 −42 38 3.51 0.002 Pcorr < 0.05
54 −24 14 3.49
48 −56 44 3.29
(c) Correlation with mood ratings
 Positive Correlation
 Whole-brain analysis
  BA 8, precentral gyrus, middle frontal gyrus L 5530 −54 6 44 4.72 0.003 Pcorr < 0.05
−30 −24 76 3.64
−48 22 46 3.41
  Brainstem R 940 18 −34 −50 3.55 0.626 Pcorr < 0.05
14 −34 −42 3.54
0 −42 −50 3.11
  Cerebellum 1312 24 −70 −44 3.06 0.410 Pcorr < 0.05
0 −74 −44 2.95
−18 −70 −46 2.77
  Superior temporal gyrus L 561 −40 −44 16 2.83 0.870 Pcorr < 0.05
−42 −48 8 2.81
−44 −42 28 2.79
 ROI Analysis
  Amygdala L 78 −30 −2 −18 3.27 0.012
  dlPFC L 1162 −54 6 42 4.71 0.002
Negative Correlation
 Whole-brain analysis
  Orbital gyrus (BA 11), ACC, putamen R 1241 12 48 −28 3.17 0.446 Pcorr < 0.05
8 30 −6 3.01
24 18 4 2.98
  Inferior parietal lobule/postcentral gyrus (BA 40) R 1653 46 −46 56 3.05 0.269 Pcorr < 0.05
52 −34 52 2.91
52 −40 46 2.86

ACC, anterior cingulate cortex; BA, Brodmann area; dlPFC, dorsolateral prefrontal cortex; FWE, family wise error correction; L, left hemisphere; R, right hemisphere; ROI, region-of-interest; sgACC, subgenual anterior cingulate cortex.

1

Cluster extent threshold was 477 voxels for the ANOVA and 540 voxels for correlation analyses.