Table 3.
Region | Side | Cluster size (voxels) | Peak MNI coordinates | Z score | P (FWE) | AlphaSim corrected1 | ||
---|---|---|---|---|---|---|---|---|
x | y | z | ||||||
(a) Happy > Neutral | ||||||||
Whole-brain analysis | ||||||||
Brainstem, cingulate gyrus (incl. BA 32), medial frontal gyrus | 4461 | −4 | 0 | −16 | 3.89 | 0.009 | Pcorr < 0.05 | |
−6 | 16 | 42 | 3.56 | |||||
−14 | 14 | 50 | 3.53 | |||||
Subgyral (parietal and frontal lobes) | L | 477 | −22 | −36 | 54 | 3.52 | 0.913 | Pcorr < 0.05 |
−28 | −38 | 38 | 3.47 | |||||
−20 | −40 | 40 | 2.75 | |||||
ROI analysis | ||||||||
sgACC | L | 507 | −4 | 2 | −16 | 3.81 | 0.005 | |
Ventral striatum | 271 | −4 | 6 | −12 | 3.38 | 0.010 | ||
Amygdala | 13 | −16 | −8 | −14 | 2.72 | 0.051 | ||
(b) Happy < Neutral | ||||||||
Whole-brain analysis | ||||||||
Inferior parietal lobule (BA 40) | R | 6112 | 56 | −42 | 38 | 3.51 | 0.002 | Pcorr < 0.05 |
54 | −24 | 14 | 3.49 | |||||
48 | −56 | 44 | 3.29 | |||||
(c) Correlation with mood ratings | ||||||||
Positive Correlation | ||||||||
Whole-brain analysis | ||||||||
BA 8, precentral gyrus, middle frontal gyrus | L | 5530 | −54 | 6 | 44 | 4.72 | 0.003 | Pcorr < 0.05 |
−30 | −24 | 76 | 3.64 | |||||
−48 | 22 | 46 | 3.41 | |||||
Brainstem | R | 940 | 18 | −34 | −50 | 3.55 | 0.626 | Pcorr < 0.05 |
14 | −34 | −42 | 3.54 | |||||
0 | −42 | −50 | 3.11 | |||||
Cerebellum | 1312 | 24 | −70 | −44 | 3.06 | 0.410 | Pcorr < 0.05 | |
0 | −74 | −44 | 2.95 | |||||
−18 | −70 | −46 | 2.77 | |||||
Superior temporal gyrus | L | 561 | −40 | −44 | 16 | 2.83 | 0.870 | Pcorr < 0.05 |
−42 | −48 | 8 | 2.81 | |||||
−44 | −42 | 28 | 2.79 | |||||
ROI Analysis | ||||||||
Amygdala | L | 78 | −30 | −2 | −18 | 3.27 | 0.012 | |
dlPFC | L | 1162 | −54 | 6 | 42 | 4.71 | 0.002 | |
Negative Correlation | ||||||||
Whole-brain analysis | ||||||||
Orbital gyrus (BA 11), ACC, putamen | R | 1241 | 12 | 48 | −28 | 3.17 | 0.446 | Pcorr < 0.05 |
8 | 30 | −6 | 3.01 | |||||
24 | 18 | 4 | 2.98 | |||||
Inferior parietal lobule/postcentral gyrus (BA 40) | R | 1653 | 46 | −46 | 56 | 3.05 | 0.269 | Pcorr < 0.05 |
52 | −34 | 52 | 2.91 | |||||
52 | −40 | 46 | 2.86 |
ACC, anterior cingulate cortex; BA, Brodmann area; dlPFC, dorsolateral prefrontal cortex; FWE, family wise error correction; L, left hemisphere; R, right hemisphere; ROI, region-of-interest; sgACC, subgenual anterior cingulate cortex.
Cluster extent threshold was 477 voxels for the ANOVA and 540 voxels for correlation analyses.