Table 3.

Top 14 candidate protein drug targets of Mycobacterium tuberculosis H37Rv

Gene Symbol	Locus	Functional class	Max-flow	Cross reference (PDB)
rpoA	Rv3457c	information pathways	70861
rpsC	Rv0707	information pathways	61418
rplJ	Rv0651	information pathways	61319
secY	Rv0732	cell wall and cell processes	49050
gdh	Rv2476c	intermediary metabolism and respiration	36008
katG	Rv1908c	virulence, detoxification, adaptation	33297	1SFZ;1SJ2;2CCA;2CCD;4C50;4C51;
glcB	Rv1837c	intermediary metabolism and respiration	31666	2GQ3;3S9I;3S9Z;3SAD;3SAZ;3SB0;
hisD	Rv1599	intermediary metabolism and respiration	30402
korA	Rv2455c	intermediary metabolism and respiration	27638
rpoZ	Rv1390	information pathways	27485
gltB	Rv3859c	intermediary metabolism and respiration	26942
dnaN	Rv0002	information pathways	24226	3P16;3RB9;
sirA	Rv2391	intermediary metabolism and respiration	23588	1ZJ8;1ZJ9;
ftsZ	Rv2150c	cell wall and cell processes	23472	1RLU;1RQ2;1RQ7;2Q1X;2Q1Y;4KWE;