Figure 1. Step Up Strategy CTP.
Non-biologic DMARD at treatment initiation followed by the option to start a biologic DMARD at 3 months or thereafter based on clinical assessment. DMARD= non-biologic DMARD; biologic= biologic DMARD; IAS= intraarticular glucocorticoid injection. DMARD choices include methotrexate, leflunomide, and sulfasalazine. Biologic choices include any inhibitor of TNF, T cell co-stimulation, IL6 or B cells.