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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Arch Biochem Biophys. 2008 Nov 8;481(2):145–150. doi: 10.1016/j.abb.2008.11.001

Figure 1. Folate-dependent one-carbon metabolism in the cytoplasm and inhibition by LY309887, Lometrexol, and Pemetrexed.

Figure 1

Products of one-carbon metabolism are underlined. Lometrexol and LY309887 inhibit GARFT. Pemetrexed primarily inhibits TS, but also inhibits other folate-dependent enzymes shown within dashed boxes. DHF, dihydrofolate; THF, tetrahydrofolate; MTHFS, methenyltetrahydrofolate synthetase; cSHMT, cytoplasmic serine hydroxymethyltransferase; GARFT, glycinamide ribonucleotide formyltransferase; AICARFT, phosphoribosylaminoimidazole carboxamide formyltransferase; DHFR, dihydrofolate reductase; TS, thymidylate synthase.