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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Curr Pharm Biotechnol. 2013;14(2):233–241. doi: 10.2174/138920113805219395

Figure 4. Simvastatin pretreatment reduces C5aR expression on macrophages.

Figure 4

RAW cells were treated with 1 µM simvastatin (SIMVA) or dimethyl sulfoxide (DMSO) 18–20 hours prior to infection with S. aureus for 1 hour (SA+DMSO and SA+ SIMVA). The infection was stopped and cells were analyzed 18 hours post-infection for expression of C5aR. Histograms (a) are from one experiment that is representative of 3 total experiments. Normalized mean fluorescence intensity (b) was pooled from all experiments and analyzed by one-way ANOVA followed by Student Neuman-Keuls post-hoc analysis. *p ≤ 0.05 compared to DMSO. **p ≤ 0.05 compared to SA+DMSO.