Table 2.
Patient characteristics of obese versus non-obese patients (N = 108)
| Obese (n=37) |
Non-Obese (n=71) |
P-value | |
|---|---|---|---|
| Age, mean (SD) | 59.3 (14.0) | 59.6 (15.4) | 0.27 |
| Male, n (%) | 13 (35.1) | 54 (76.1) | < 0.001 |
| Ethnicity, n (%) | 0.70 | ||
| Caucasian | 4 (10.8) | 6 (8.5) | |
| African American | 29 (78.4) | 53 (74.6) | |
| Asian | 0 (0) | 3 (4.2) | |
| Hispanic | 3 (8.1) | 8 (11.3) | |
| Other | 1 (2.7) | 1 (1.4) | |
| Total body weight (kg), mean (SD) | 106.2 (20.8) | 71.9 (13.3) | < 0.001 |
| Body mass index (kg/m2), mean (SD) | 36.7 (6.4) | 23.9 (3.1) | < 0.001 |
| Comorbidities, n (%) | |||
| Diabetes | 16 (43.2) | 18 (25.4) | 0.057 |
| Hypertension | 24 (64.9) | 41 (57.7) | 0.47 |
| Heart failure | 2 (5.4) | 1 (1.4) | 0.27 |
| Ascites | 0 (0) | 1 (1.4) | 1.00 |
| Concurrent nephrotoxins, mean (SD) | 1.0 (1.1) | 1.1 (1.1) | 0.65 |
| Type of Infection, n (%) | |||
| Bloodstream | 3 (8.1) | 7 (9.9) | 1.00 |
| Lungs | 15 (40.5) | 30 (42.3) | 0.86 |
| Cerebrospinal fluid | 1 (2.7) | 4 (5.6) | 0.66 |
| Urinary tract | 1 (2.7) | 5 (7.0) | 0.66 |
| Bone | 8 (21.6) | 12 (16.9) | 0.55 |
| Skin | 1 (2.7) | 1 (1.4) | 1.00 |
| Neutropenic fever | 0 (0) | 3 (4.2) | 0.55 |
| Sepsis | 21 (56.8) | 42 (59.2) | 0.63 |
| Renal function, mean (SD) | |||
| Baseline serum creatinine (mg/dL) | 0.99 (0.31) | 0.94 (0.21) | 0.52 |
| End serum creatinine (mg/dL) | 0.94 (0.22) | 0.92 (0.22) | 0.31 |
| Baseline creatinine clearance (mL/min) | 86.2 (24.6) | 82.0 (25.6) | 0.34 |
| End creatinine clearance (mL/min) | 89.2 (24.4) | 84.3 (26.3) | 0.35 |
| APACHE II* Score, mean (SD) | 12.7 (8.4) | 13.4 (7.5) | 0.39 |
| SOFA*Score, mean (SD) | 3.0 (2.8) | 3.3 (1.9) | 0.07 |
*
Abbreviations: APACHE II = Acute Physiology And Chronic Health Evaluation II; SOFA = Sequential Organ Failure Assessment