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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neurobiol Dis. 2015 May 21;80:70–79. doi: 10.1016/j.nbd.2015.04.016

Figure 4. Lack of evidence for systemic inflammation in Tsc1GFAPCKO mice.

Figure 4

Serum inflammatory markers were assessed in Tsc1GFAPCKO mice to evaluate the potential involvement of the peripheral immune system in contributing to brain inflammation. There was no significant difference in serum IL-1β (A) and CXCL10 (B) protein levels as assayed by ELISA in 4 week-old Tsc1GFAPCKO mice compared with control mice, while LPS induced a significant increase in these markers in control mice. * p<0.05, *** p<0.001, versus vehicle-treated control mice by one-way ANOVA; ## p<0.01, ### p<0.001, versus vehicle-treated Tsc1GFAPCKO mice by one-way ANOVA (n = 5–9 mice/group). Cont = control, KO = Tsc1GFAPCKO.