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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neurobiol Dis. 2015 May 21;80:70–79. doi: 10.1016/j.nbd.2015.04.016

Figure 6. ECG treatment does not prevent neuronal disorganization in Tsc1GFAPCKO mice.

Figure 6

The effect of ECG on neuronal organization was assessed in Tsc1GFAPCKO mice by cresyl violet staining. Compared with control mice (A), vehicle-treated Tsc1GFAPCKO mice (B) exhibited widely dispersed pyramidal cell layers (arrows) in all regions of hippocampus (CA1–CA4). ECG treated Tsc1GFAPCKO mice (C) had a similar pattern as vehicle-treated Tsc1GFAPCKO group (B), with no apparent effect on this neuronal disorganization. Scale bar = 500 μm. Cont = control mice, KO = Tsc1GFAPCKO mice, Veh = vehicle, ECG = Epicatechin-3-gallate.