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. Author manuscript; available in PMC: 2016 Mar 10.
Published in final edited form as: Oncogene. 2014 Dec 15;34(37):4845–4854. doi: 10.1038/onc.2014.406

Figure 4. Significance of RAF family fusions in thyroid cancer.

Figure 4

(A) The top panel indicates frequencies of somatic mutations (lightblue) and significant mutations (pink). To compare the frequency between samples with and without recurrent fusions (n≥2), a Welch’ s t-test was performed. The bottom panel shows a heatmap of fusions and significant gene mutations in 312 thyroid cancers. (B) Position of each domain in BRAF gene and junction points of BRAF fusions. (C) Exon expression plots demonstrated Z-normalized exon expression for each exon in thyroid cancers. Red and blue represent relatively high and low exon expression.