Fig 6. 129:Stat1-null fat pads poorly support growth of transplanted tumors.
Tumor volume changes in mammary glands of 129SvEv WT or 129:Stat1-null (Stat1-null) host mice over time. Explants of three primary mammary gland tumors from Stat1-null mice were transplanted into inguinal mammary glands of five 129SvEv WT or Stat1-null hosts. Tumors were measured by caliper twice weekly for 7 weeks. Tumor volumes in 129SvEv WT mice increased 10-fold faster than those in Stat1-null hosts. Data are mean ± SEM (n = 5), ***P<0.001. Each horizontal black bar represents the mean of tumor volumes.