Table 2. Univariate analysis for overall survival in the development set.
| Characteristics | HR | 95% CI | P value |
|---|---|---|---|
| Age at diagnosis (median, range) | |||
| < 65 | 1.000 | ||
| ≥ 65 | 1.597 | 1.258–2.028 | < 0.001 |
| Gender | |||
| Male | 1.000 | ||
| Female | 1.171 | 0.909–1.510 | 0.222 |
| Tumor size (median, range) | |||
| ≤ 4.5 cm | 1.000 | ||
| > 4.5 cm | 2.725 | 2.119–3.505 | < 0.001 |
| Tumor location | |||
| Lower 1/3 | 1.000 | ||
| Middle 1/3 | 1.236 | 0.876–1.745 | 0.228 |
| Upper 1/3 | 1.730 | 1.046–2.861 | 0.033 |
| 2/3 or more | 2.070 | 1.568–2.733 | < 0.001 |
| Lauren type | |||
| Intestinal | 1.000 | ||
| Diffuse | 1.657 | 1.262–2.176 | < 0.001 |
| Mixed | 1.706 | 1.228–2.370 | 0.001 |
| Depth of invasion | |||
| T1 | 1.000 | ||
| T2 | 6.344 | 2.402–16.753 | < 0.001 |
| T3 | 13.316 | 5.274–33.619 | < 0.001 |
| T4 | 21.167 | 8.715–51.409 | < 0.001 |
| Metastatic LNs, No. | |||
| 0 | 1.000 | ||
| 1–2 | 3.050 | 1.942–4.789 | < 0.001 |
| 3–6 | 4.140 | 2.685–6.385 | < 0.001 |
| 7–15 | 7.955 | 5.300–11.939 | < 0.001 |
| >15 | 10.688 | 7.030–16.248 | < 0.001 |
| Histology grade | |||
| G1-G2 | 1.000 | ||
| G3-G4 | 1.361 | 1.024–1.809 | 0.033 |
| Lymphovascular invasion | |||
| Negative | 1.000 | ||
| Positive | 2.549 | 2.014–3.227 | < 0.001 |
| WBC count (×103 mm-3) | |||
| ≤ 9.5 | 1.000 | ||
| > 9.5 | 1.440 | 0.991–2.093 | 0.056 |
| Neutrophil count (×103 mm-3) | |||
| ≤ 6.3 | 1.000 | ||
| > 6.3 | 1.438 | 0.999–2.069 | 0.050 |
| Lymophocyte count (×103 mm-3) | |||
| < 1.1 | 1.000 | ||
| ≥ 1.1 | 0.611 | 0.441–0.846 | 0.003 |
| Platelet count (×103 mm-4) | |||
| ≤ 350 | 1.000 | ||
| > 350 | 1.222 | 0.797–1.873 | 0.357 |
| NLR | |||
| ≤ 50th percentile | 1.000 | ||
| > 50th percentile | 1.648 | 1.296–2.095 | < 0.001 |
| PLR | |||
| ≤ 75th percentile | 1.000 | ||
| > 75th percentile | 1.762 | 1.372–2.264 | < 0.001 |
| Hemoglobin (g/l) | |||
| < 115 | 1.000 | ||
| ≥ 115 | 0.713 | 0.557–0.913 | 0.007 |
| Serum albumin (g/l) | |||
| < 40 | 1.000 | ||
| ≥ 40 | 0.674 | 0.533–0.853 | 0.001 |
| Plasma fibrinogen (mg/dl) | |||
| ≤ 400 | 1.000 | ||
| > 400 | 1.724 | 1.351–2.200 | < 0.001 |
Abbreviations: LNs, lymph nodes; G1, well differentiated; G2, moderately differentiated; G3, poorly differentiated; G4, undifferentiated; WBC, white blood cells; NLR, neutrophil—lymphocyte ratio; PLR, platelet—lymphocyte ratio; HR, hazard ratio; CI, confidence interval.