Table 4. Lead Insulation vs. Late Heart Perforation and Infection Under Cox Logistic Regression Analysis.

	Number of Event––no. (%)			Adjusted Hazard Ratio and 95% CI
	Silicone	Polyurethane	Combined	Silicone vs. Combined		Polyurethane vs. Combined		Silicone vs. Polyurethane
Outcome	(n = 21,409)	(n = 3,073)	(n = 1,565)	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Late heart perforation	9 (0.04)	2 (0.07)	0 (0.00)	NA	NA	NA	NA	0.51 (0.11–2.44)	0.399
Infection	144 (0.67)	21 (0.68)	10 (0.64)	1.11 (0.58–2.13)	0.742	1.15 (0.54–2.47)	0.716	0.97 (0.61–1.54)	0.889
Early vs. late
Early infection	101 (0.47)	15 (0.49)	6 (0.38)	1.38 (0.60–3.16)	0.447	1.43 (0.55–3.72)	0.467	0.97 (0.56–1.67)	0.906
Late infection	43 (0.20)	6 (0.20)	4 (0.26)	0.73 (0.26–2.06)	0.553	0.76 (0.21–2.77)	0.683	0.95 (0.40–2.26)	0.915
Need of lead-extraction vs. without lead extraction
Need of lead-extraction	82 (0.38)	17 (0.55)	6 (0.38)	1.05 (0.45–2.41)	0.915	1.51 (0.59–3.88)	0.390	0.69 (0.41–1.17)	0.172
Without lead-extraction	62 (0.29)	4 (0.13)	4 (0.26)	1.25 (0.45–3.47)	0.670	0.61 (0.15–2.47)	0.487	2.06 (0.74–5.68)	0.165

The hazard ratios (OR) were adjusted for all covariates listed in Table 1.