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. 2015 Jun 15;10(6):e0129884. doi: 10.1371/journal.pone.0129884

Fig 1. Identification of AcLAP as an M17 aminopeptidase of Acanthamoeba castellanii.

Fig 1

Multiple alignment of the deduced amino acid sequence of AcLAP with leucine aminopeptidase (LAP) sequences of human (GenBank accession no. CAG33409) (48% amino acid identity), Leishmania major (GenBank accession no. XP_001683430) (58% amino acid identity), and Plasmodium falciparum (GenBank accession no. AAN37052) (66% amino acid identity) was performed using ClustalW software. Black and gray boxes indicate identical and conserved amino acids, respectively. The M17 aminopeptidase family signature sequence, NTDAEGRL, is indicated by a box with a dashed border. Metal-coordinating residues and active-site residues are indicated by closed triangles and asterisks, respectively.