The increased levels of serum salic acid (SA) and sialylated glycoproteins in LCMM patients were clarified by enzymatic method and using lectin blot, respectively. (A): The horizontal axis represents the experimental groups: control (n = 42), LCMM (n = 42). The vertical axis indicates the serum SA level (mg/dl), and error bars are mean ± standard deviations. (B) and (C): Lectin blots of serum glycoproteins were probed with MAL II and SNA representing the α-2,3-linked and α-2,6-linked sialylated proteins. The horizontal axis represents the experimental groups: control (n = 20) and LCMM (n = 20). The vertical axis indicates the fluorescence intensity ratio of MAL II or SNA binding proteins to total proteins stained by coomassie blue (CBB), and error bars are mean ± standard deviations. MAL II binding α-2,3-linked sialylated protein increased in LCMM patients, whereas there was no significant change in SNA binding α-2,6-linked sialylated proteins between LCMM patients and controls.