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. 2015 Jun 15;10(6):e0129566. doi: 10.1371/journal.pone.0129566

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© 2015 Rozanov et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — (A) a pharmacophore analog of ML100, NSC130362, exhibited potent anti-cancer activity and was non-toxic to human hepatocytes. The effect of NSC130362 (inset) on the viability of MDA-MB-435, DU145 cells and hepatocytes was determined in a TRAIL-based combined treatment as described in the legend for Fig 2. *, P < 0.05. (B) both ML100 and NSC130362 synergistically induced caspase 3/7 activity in MDA-MB-435 cells. MDA-MB-435 cells were pre-incubated with ML100 and NSC130362 for 2 h followed by TRAIL treatment for 2 and 6 h, respectively. Caspase 3/7 activity was measured by Caspase 3/7 Lux assay (Promega). *, P < 0.05.