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. 2015 Jun 15;10(6):e0129566. doi: 10.1371/journal.pone.0129566

Fig 8. Combined treatment of NSC130362 and oxidative stress inducers ATO, Myr, and BSO efficiently induced apoptosis in a variety of cancer cells but not in primary human hepatocytes.

Fig 8

The effect of NSC130362/ATO (A), NSC130362/Myr (B), and NSC130362/BSO (C) combined treatment in breast carcinoma cells and MDA-MB-435 melanoma cells. The effect of NSC130362/ATO and NSC130362/Myr (D) combined treatment in pancreatic, prostate, and lung carcinoma cells as well as in AML cells from cancer patients. Subconfluent cells in a 96-well plate were pre-incubated for 4 h with ATO (3 μM), Myr (100 μM), or BSO (10 μM) followed by treatment with NSC130362 (10 μM) for an additional 24 h. At the end of the treatment, the ratio of dead cells was determined by an ATPLite reagent. *, P < 0.05.