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. 2015 Jun 15;10(6):e0130076. doi: 10.1371/journal.pone.0130076

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© 2015 Adamo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — The rows represent expression levels for each of the 461 genes that were differentially expressed between TINT and normal prostate control tissue and the columns represent the signature of each sample (normal, TINT and tumor). Red color illustrates higher expression than the mean expression in normal prostate tissue and blue illustrates lower expression. Genes were hierarchical clustered using average linkage clustering with a pearson correlation. Three major gene clusters were identified: A) genes down-regulated in TINT and tumour vs. normal tissue, B) genes mainly up-regulated in both TINT and tumor tissue vs. normal tissue and C) genes exclusively up-regulated in TINT vs. normal control tissue. TINT: tumor-adjacent normal prostate tissue.