Table 1. Quantification of morphological changes in the tumor-bearing organ (TINT-changes) in rats carrying AT-1 tumors and in different controls.
AT-1 tumors | RPMI-medium controls | Heat-killed AT-1 controls | |
---|---|---|---|
Volume density of CD68 + cells (%) | 1.1 +/- 0.46 a | 0.18 +/- 0.075 | 0.18+/-0.094 b |
Volume density of blood vessels (%) | 1.9 +/- 0.34 a | 0.86 +/- 0.20 | 0.75+/-0.26 b |
Endothelial BrdU- labeling index | 23 +/- 5.1 a | 1.3 +/- 0.45 | 1.5+/-0.64 b |
Volume density of Mast cells (%) | 0.34 +/- 0.10 a | 0.20 +/- 0.10 | 0.20 +/-0.060 b |
Values are means +/- SD, n = 7–9 animals in each group.
a Significantly different than in both controls,
b Not significantly different from that in RPMI injected animals, p < 0.05