Table 2.

Class, common compound, HDAC target, and main functions of HDACis.

Class	Compound	HDAC target	Function	References
Hydroxamic acids	TsA SAHA LBH589 PXD101	Classes I and II Classes I and II Classes I and II Classes I and II	A, D, GA, P, CP, R, NG, and AI A, CP, S, TR, and AI A, GA, TR, and P A, GA, and TR	[21, 22, 41, 42, 88] [21, 67, 69, 70, 74] [21, 33, 89] [21, 33]
Cyclic peptides	FK228	Class I	A, GA, D, and TR	[21, 33, 90]
Benzamides	MS-275 MGCD0103	HDACs 1, 2, and 3 Class I	A, D, S, and GA A, TR, AI, and GA	[21, 77] [21, 91, 92]
Aliphatic acids	VPA PBA NaB	Classes I and IIa Classes I and IIa Classes I and IIa	A, AI, TR, S, D, and GA A, D, and GA A, D, GA, AI, TR, S, and NG	[10, 11, 21, 51] [21, 93, 94] [11, 15, 21, 57]

A: cell apoptosis/death; AI: anti-inflammatory effect; TR: transcriptional regulation; NG: neurogenesis; S: cell survival; CP: cell-cycle progression; P: proliferation; R: regeneration; D: differentiation; GA: growth arrest.