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Illustration for the mechanism underlying s-IL-15Rα–induced EMT, migration, and invasion of human RCCs. When s-IL-15Rα binds to tmb-IL-15 in RCC, Src-dependent PI3K/Akt/GSK-3β/β-catenin pathway is activated and responsible for EMT induction. However, Src-FAK and Src-Erk1/2 signaling are also triggered by s-IL-15Rα/tmb-IL-15 interaction and involved in s-IL-15Rα–induced migration and invasion properties of RCC.
