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. 2015 May 27;17(5):421–433. doi: 10.1016/j.neo.2015.04.003

Figure 2.

Figure 2

Similar angiogenic microenvironments in the MMTV-Neu and C3(1)-Tag mouse models of breast cancer. (A) The vascularity, as determined by the tumor area staining for the endothelial marker CD31, was similar in MMTV-Neu (n = 8) and C3(1)-Tag tumors (n = 8). (B) Relative protein levels of a panel of angiogenic factors measured on whole-tumor lysates from MMTV-Neu (n = 3) and C3(1)-Tag (n = 3) tumors. Each column represents a tumor from an individual mouse. The measured protein levels were normalized to an internal assay standard and plotted in a heat map. Statistical significance was determined by t tests using the Holm- Šídák method to correct for multiple comparisons, and the asterisk indicates P < .05.